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Silifar

Ask a doctor about a prescription for Silifar

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Silifar

Leaflet attached to the packaging: information for the user

Sylifar

140 mg of silymarin in terms of silybin, hard capsules

Silybi mariani extractum siccum raffinatum et normatum

Please read the contents of the leaflet carefully before using the medicine, as it contains important information for the patient.

This medicine should always be used exactly as described in the patient leaflet or as directed by a doctor or pharmacist.

  • Please keep this leaflet, so that you can read it again if you need to.
  • If you need advice or additional information, you should consult a pharmacist.
  • If the patient experiences any side effects, including any possible side effects not listed in the leaflet, they should inform their doctor or pharmacist. See section 4.
  • If after 2 weeks of use, there is no improvement or the patient feels worse, they should contact their doctor.

Table of contents of the leaflet

  • 1. What is Sylifar and what is it used for
  • 2. Important information before using Sylifar
  • 3. How to use Sylifar
  • 4. Possible side effects
  • 5. How to store Sylifar
  • 6. Contents of the packaging and other information

1. What is Sylifar and what is it used for

Sylifar is a traditional herbal medicinal product for use in specified indications, resulting solely from its long-term use.
Sylifar contains a dry extract of milk thistle fruit in its composition. The active substance of milk thistle fruit is a complex of flavonoids called silymarin, which includes, among others, silybin.
The traditional herbal medicinal product is used for the symptomatic treatment of digestive disorders, feelings of fullness and indigestion, as well as to support liver function, after excluding serious diseases by a doctor.
If after 2 weeks, there is no improvement or the patient feels worse, they should consult their doctor.

2. Important information before using Sylifar

When not to use Sylifar:

Warnings and precautions

Before starting to use Sylifar, the patient should discuss it with their doctor or pharmacist.
The medicine should not be used to treat acute poisonings.
Harmful factors for the liver (such as alcohol) should be avoided.
If symptoms of jaundice (light to dark yellow discoloration of the skin, yellow discoloration of the eyes) occur, the patient should consult their doctor.
If the symptoms worsen during the use of the medicinal product, the patient should consult their doctor.

Children and adolescents

Due to the lack of data confirming the safety of use, it is not recommended to use the medicine in children under 18 years of age.

Sylifar and other medicines

The patient should tell their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
No interactions have been found during use with other medicines.

Sylifar with food, drink, and alcohol

It is recommended to use the medicine before a meal.

Pregnancy, breastfeeding, and fertility

If the patient is pregnant or breastfeeding, thinks they may be pregnant, or plans to have a child, they should consult their doctor or pharmacist before using this medicine.
The safety of the medicinal product during pregnancy and breastfeeding has not been established.
The use of the medicine during pregnancy and breastfeeding is not recommended due to the lack of sufficient data.

Driving and using machines

No studies have been conducted on the effect of silymarin on the ability to drive and use machines.

Sylifar contains orange yellow (E110) and azorubine (E122).

The medicine may cause allergic reactions.
The medicine contains less than 1 mmol (23 mg) of sodiumper recommended dose, which means the medicine is considered "sodium-free".

3. How to use Sylifar

This medicine should always be used exactly as described in the patient leaflet or as directed by a doctor or pharmacist. If in doubt, the patient should consult their doctor or pharmacist.
At the beginning of treatment, it is recommended to take 1 capsule 3 times a day (which corresponds to 420 mg of silymarin). As a maintenance dose, it is recommended to take 1 capsule 2 times a day (which corresponds to 280 mg of silymarin).
The medicine should be taken whole, without chewing or crushing, before a meal, with a small amount of liquid.
The patient should consult their doctor if the symptoms persist for more than 2 weeks after starting the use of the medicine.

Use in children

Due to the lack of data confirming the safety of use, it is not recommended to use the medicine in children under 18 years of age.

Overdose of Sylifar

There are no data on the symptoms of overdose.

Missed dose of Sylifar

A double dose should not be taken to make up for a missed dose.

Stopping the use of Sylifar

In case of any further doubts related to the use of this medicine, the patient should consult their doctor or pharmacist.

4. Possible side effects

Like all medicines, Sylifar can cause side effects, although not everybody gets them.
During use, mild gastrointestinal disorders, such as dry mouth, nausea, stomach upset, stomach irritation, and diarrhea, may occur. Headache, allergic reactions (skin inflammation, hives, rash, itching, anaphylaxis, asthma), have also been observed. The frequency of these side effects is unknown.

Reporting side effects

If any side effects occur, including any side effects not listed in the leaflet, the patient should inform their doctor or pharmacist. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products, Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products, Al. Jerozolimskie 181 C, 02-222 Warsaw, Tel. 48 22 49 21 301, fax 48 22 49 21 309, e-mail: [email protected].
Side effects can also be reported to the marketing authorization holder.
Reporting side effects will allow for more information to be gathered on the safety of the medicine.

5. How to store Sylifar

Store in a temperature below 30°C.
Store in a place out of sight and reach of children.
Do not use Sylifar after the expiry date stated on the packaging. The expiry date refers to the last day of the specified month.
Medicines should not be disposed of via wastewater or household waste containers. The patient should ask their pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. Contents of the packaging and other information

What Sylifar contains

The active substance of Sylifar is a dry, purified, and standardized extract of milk thistle fruit (Silybi mariani extractum siccum raffinatum et normatum).

  • One capsule contains 241.35 mg of extract (in the form of a dry, purified extract from Silybum marianum(L.) Gaertn., fructus (milk thistle fruit) (22-27:1), which corresponds to 140 mg of silymarin in terms of silybin. The extraction solvent is aceton 95% (V/V).

The nominal content of silymarin in terms of silybin in the extract is 58% (m/m).

  • The other ingredients are: Capsule content: microcrystalline cellulose, colloidal anhydrous silica, meglumine, sodium carboxymethyl cellulose type A, magnesium stearate. Capsule shell: gelatin, titanium dioxide (E171), quinoline yellow (E104), azorubine (E122), patent blue V (E131), orange yellow FCF (E110).

What Sylifar looks like and what the packaging contains

Sylifar are red and dark green hard capsules containing a brown mixture.
The hard capsules are packaged in PVC/PVDC/Aluminum blisters, together with the patient leaflet, in a cardboard box.
The packaging contains 10, 20, 30, 60, or 100 hard capsules.
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Biofarm Sp. z o.o.
ul. Wałbrzyska 13
60-198 Poznań
Tel. +48 61 66 51 500

Date of the last update of the leaflet:

  • Country of registration
  • Active substance
  • Prescription required
    No
  • Manufacturer
  • Importer
    Biofarm Sp. z o.o.
  • Alternatives to Silifar
    Dosage form: Tablets, 150 mg
    Active substance: silymarin
    Prescription not required
    Dosage form: Tablets, 150 mg
    Active substance: silymarin
    Prescription not required
    Dosage form: Tablets, 150 mg
    Active substance: silymarin
    Prescription not required

Alternatives to Silifar in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Silifar in Ukraine

Dosage form: capsules, 70 mg, 10 capsules in a blister
Active substance: silymarin
Dosage form: capsules, capsules 140mg
Active substance: silymarin
Dosage form: capsules, 140 mg
Active substance: silymarin
Manufacturer: MADAUS GmbH
Prescription not required
Dosage form: tablets, 22.5 mg
Active substance: silymarin
Prescription not required
Dosage form: capsules, 90 mg capsules in blister
Active substance: silymarin
Manufacturer: AT "Sofarma
Prescription not required

Alternative to Silifar in Spain

Dosage form: CAPSULE, 100 mg Dry extract of milk thistle (equivalent to 80 mg of silymarin)
Active substance: silymarin
Prescription required
Dosage form: CAPSULE, 150 mg silymarin
Active substance: silymarin
Prescription required
Dosage form: CAPSULE, 300 mg
Prescription not required
Dosage form: INJECTABLE PERFUSION, 350 mg sodium silibinate
Prescription required
Dosage form: TABLET, 4.6 mg dry extract Cynara scolimus (1:30-31); 1.2 mg dry extract Taraxacum officinalis (1:17-18); 0.7 mg dry extract Peumus boldus (1:10-11); 3.2 mg dry extract Silibum marianum (1:2-2.1)
Prescription not required
Dosage form: CAPSULE, 390 mg
Prescription not required

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For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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