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Rupafin

Rupafin

Ask a doctor about a prescription for Rupafin

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Rupafin

PATIENT INFORMATION LEAFLET: USER INFORMATION

Warning! The leaflet should be kept. Information on the immediate packaging in a foreign language.

Rupafin, 1 mg/ml, oral solution

Rupatadine

It is necessary to carefully read the contents of the leaflet before taking the medicine, as it contains important information for the patient.

  • The leaflet should be kept so that it can be re-read if necessary.
  • In case of any doubts, you should consult a doctor or pharmacist.
  • This medicine has been prescribed to a specific person. It should not be given to others. The medicine may harm another person, even if the symptoms of their disease are the same.
  • If the patient experiences any side effects, including any side effects not listed in this leaflet, they should inform their doctor, pharmacist, or nurse. See section 4.

Table of contents of the leaflet:

  • 1. What is Rupafin and what is it used for
  • 2. Important information before taking Rupafin
  • 3. How to take Rupafin
  • 4. Possible side effects
  • 5. How to store Rupafin
  • 6. Package contents and other information

1. What is Rupafin and what is it used for

Rupafin contains the active substance rupatadine, which is an antihistamine.
Rupafin oral solution relieves symptoms of allergic rhinitis, such as
sneezing, nasal discharge, feeling of a blocked nose, itching of the eyes and nose in children aged 2 to
11 years.
Rupafin is also used to relieve symptoms associated with urticaria (allergic skin rash), such as
itching and hives (local skin redness and swelling) in children aged 2 to 11 years.

2. Important information before taking Rupafin

When not to take Rupafin

  • If the patient is allergic to rupatadine or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Before starting to take Rupafin, the patient should discuss it with their doctor or pharmacist.
If the patient has kidney or liver failure, they should consult their doctor.
Currently, it is not recommended to use Rupafin in patients with kidney or liver function disorders.
If the patient has low potassium levels in the blood and/or an abnormal heart rhythm (known as QTc interval prolongation in the ECG), which may occur in some heart diseases, they should consult their doctor.

Children

This medicine is not intended for use in children under 2 years of age or weighing less than 10 kg.
Page 1 of 4

Rupafin and other medicines

The patient should tell their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
If the patient is taking Rupafin, they should not take medicines containing ketokonazole (a medicine used to treat fungal infections) or erythromycin (a medicine used to treat bacterial infections).
If the patient is taking medicines that affect the central nervous system, statins (medicines used to treat high cholesterol), or midazolam (a short-acting sedative), they should consult their doctor before taking Rupafin.

Rupafin with food, drink, and alcohol

Rupafin can be taken with or without food.
Rupafin should not be taken at the same time as grapefruit juice, as it may increase the level of Rupafin in the body.
A dose of 10 mg of Rupafin does not increase drowsiness caused by alcohol.

Pregnancy and breastfeeding

If the patient is pregnant or breastfeeding, thinks they may be pregnant, or plans to have a child, they should consult their doctor or pharmacist before taking this medicine.

Driving and using machines

It is not expected that Rupafin, when used as recommended, will affect the ability to drive or use machines. However, if the patient is taking Rupafin for the first time, they should be cautious and observe their reaction to the medicine before driving or using machines.

Rupafin contains sucrose, methyl parahydroxybenzoate (E 218), and propylene glycol

This medicine contains sucrose, which may have a harmful effect on teeth. If the patient has previously been diagnosed with intolerance to some sugars, they should consult their doctor before taking this medicine.
This medicine contains methyl parahydroxybenzoate, which may cause allergic reactions (possible late reactions).
The medicine contains 200 mg of propylene glycol in each ml.
Before administering this medicine to a child under 5 years of age, the patient should consult their doctor or pharmacist, especially if the child is taking other medicines containing propylene glycol or alcohol.
Pregnant or breastfeeding women should not take this medicine without consulting their doctor.
The doctor may decide to perform additional tests on such patients.
Patients with liver or kidney function disorders should not take this medicine without consulting their doctor. The doctor may decide to perform additional tests on such patients.
The medicinal product contains less than 1 mmol (23 mg) of sodium per 1 ml, which means the medicine is considered "sodium-free".

3. How to take Rupafin

Rupafin should always be taken as directed by the doctor. In case of doubts, the patient should consult their doctor or pharmacist.
Rupafin oral solution is intended for oral use.
Page 2 of 4
Dosing in children with a body weight of 25 kg or more:5 ml (5 mg of rupatadine) of oral solution once a day, with or without food.
Dosing in children with a body weight of 10 kg or more, but less than 25 kg:2.5 ml (2.5 mg of rupatadine) of oral solution once a day, with or without food.
The doctor will inform the patient how long the treatment with Rupafin will last.
Method of administration:

  • To open the bottle, the patient should press the cap and turn it in the opposite direction to the clockwise direction.
  • Take the syringe and place it in the perforated cork, turn the bottle upside down.
  • Fill the syringe with the prescribed dose.
  • Administer the solution directly from the dosing syringe.
  • After use, wash the syringe.

Taking a higher dose of Rupafin than recommended

If the patient has accidentally taken a large dose of the medicine, they should immediately consult their doctor or pharmacist.

Missing a dose of Rupafin

The patient should not take a double dose to make up for a missed dose.

4. Possible side effects

Like all medicines, Rupafin can cause side effects, although not everybody gets them.
Common side effects (may affect up to 1 in 10 people) include: headache and drowsiness. Uncommon side effects (may affect up to 1 in 100 people) include: flu, pharyngitis, upper respiratory tract infection, eosinophilia, neutropenia, dizziness, nausea, rash, night sweats, and fatigue.

Reporting side effects

If the patient experiences any side effects, including any side effects not listed in the leaflet, they should inform their doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products, Al. Jerozolimskie 181C, 02-222 Warsaw, tel.: +48 22 49 21 301, fax: +48 22 49 21 309, website: https://smz.ezdrowie.gov.pl
By reporting side effects, it is possible to gather more information on the safety of the medicine.

5. How to store Rupafin

There are no special precautions for storage.
Store in a place out of sight and reach of children.
Do not use Rupafin after the expiry date stated on the packaging.
The expiry date refers to the last day of the month stated.
The shelf life after first opening is the same as the expiry date stated on the packaging.
Page 3 of 4
Medicines should not be disposed of via wastewater or household waste. The patient should ask their pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package contents and other information

What Rupafin contains

  • The active substance is rupatadine. Each ml contains 1 mg of rupatadine (as rupatadine fumarate).
  • Other ingredients are: propylene glycol, citric acid, disodium phosphate, sodium saccharin, sucrose, methyl parahydroxybenzoate (E 218), quinoline yellow (E 104), banana flavor, purified water. See section 2 "Rupafin contains sucrose, methyl parahydroxybenzoate (E 218), and propylene glycol".

What Rupafin looks like and what the pack contains

Rupafin is a clear, yellow oral solution.
Rupafin is packaged in a brown PET bottle with a perforated LDPE cork, with an HDPE child-resistant closure and a 5 ml PP/PE oral dosing syringe with 0.25 ml gradations, in a cardboard box.
For more detailed information, the patient should contact the marketing authorization holder or the parallel importer.

Marketing authorization holder in Bulgaria, the country of export:

Noucor Health, S.A., Av. Camí Reial, 51-57, 08184 Palau-solità i Plegamans (Barcelona), Spain

Manufacturer:

Italfarmaco S.A., San Rafael, 3, Pol. Ind. Alcobendas, 28108 Alcobendas (Madrid), Spain
Recipharm Parets S.L., Ramón y Cajal, 2, 08150 Parets del Vallés, Spain

Parallel importer:

Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź

Repackaged by:

Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź
Bulgarian, the country of export, marketing authorization number: 20130384

Parallel import authorization number: 110/20

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

Rupatall
Belgium, Luxembourg
Rinialer
Malta, Portugal
Rupafin
Austria, Bulgaria, Croatia, Cyprus, Denmark, Estonia,
Greece, Spain, Netherlands, Ireland, Iceland, Liechtenstein, Lithuania, Latvia, Germany,
Norway, Poland, Slovakia, Slovenia, Italy
Rupatadine
United Kingdom
Wystamm
France
Tamalis
Czech Republic, Romania, Hungary
Pafinur Finland, Sweden

Date of approval of the leaflet: 04.04.2025

[Information about the trademark]
Page 4 of 4

Alternatives to Rupafin in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Rupafin in Hiszpania

Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Manufacturer: Teva Pharma S.L.U.
Prescription required
Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Manufacturer: Mabo Farma S.A.
Prescription required
Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Manufacturer: Kern Pharma S.L.
Prescription required
Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Prescription required
Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Prescription required
Dosage form: TABLETKA, 10 mg
Active substance: rupatadine
Manufacturer: Laboratorios Ern S.A.
Prescription required

Alternative to Rupafin in Ukraina

Dosage form: tablets, tablets 10mg
Active substance: rupatadine
Manufacturer: NOUKOR HELS, S.A
Prescription required
Dosage form: solution, 1 mg/ml; 120 ml in a bottle
Active substance: rupatadine
Manufacturer: Italfarmako, S.A.
Prescription required
Dosage form: tablets, tablets 10mg
Active substance: rupatadine
Prescription required
Dosage form: solution, 1 mg/ml, 100 ml in a bottle
Active substance: rupatadine
Manufacturer: AT "Farmak
Prescription required

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