Izotek 20 mg

PACKAGE LEAFLET: INFORMATION FOR THE USER

Warning! Keep the leaflet, information on the immediate packaging in a foreign language!

Izotek 20 mg(A-CNOTREN)

20 mg, soft capsules

Isotretinoin
Izotek 20 mg and A-CNOTREN are different trade names for the same medicine.

WARNING

IT CAN SERIOUSLY HARM AN UNBORN CHILD
Women must use effective methods of contraception.
Do not use during pregnancy or suspected pregnancy.

You should carefully read the contents of the leaflet before using the medicine, as it contains important information for the patient.

• You should keep this leaflet so that you can read it again if you need to.
• If you have any doubts, you should consult a doctor or pharmacist.
• This medicine has been prescribed specifically for you. Do not pass it on to others. The medicine may harm another person, even if their symptoms are the same as yours.
• If you experience any side effects, including those not listed in this leaflet, you should tell your doctor or pharmacist. See section 4.

Table of contents of the leaflet

• 1. What is Izotek 20 mg and what is it used for
• 2. Important information before taking Izotek 20 mg
• 3. How to take Izotek 20 mg
• 4. Possible side effects
• 5. How to store Izotek 20 mg
• 6. Contents of the pack and other information

1. What is Izotek 20 mg and what is it used for

Izotek 20 mg contains the active substance isotretinoin - a substance similar to vitamin A and belonging to a group of medicines called retinoids (used in the treatment of acne).
Izotek 20 mg is used to treat severe forms of acne(such as nodular or conglobate acne or acne with a risk of permanent scarring) in adults and adolescents over 12 years of age, only after puberty. Izotek 20 mg will be used only if the severity of acne cannot be alleviated with other anti-acne medications, including antibiotics and topical treatments.
Treatment with Izotek 20 mg must be supervised by a dermatologist(a doctor specializing in the treatment of skin diseases).

2. Important information before taking Izotek 20 mg

When not to take Izotek 20 mg:

• If the patient is hypersensitive to isotretinoin, peanuts, or soy, or any of the other ingredientsof this medicine (listed in section 6),
• If the patient is pregnant or breastfeeding,
• If there is a risk that the patient may become pregnant, it is necessary to follow the precautions listed in the Pregnancy Prevention Program, see "Warnings and precautions" section
• For women who may become pregnant but cannot or do not want to follow the necessary pregnancy prevention measureslisted in the Pregnancy Prevention Program for Izotek 20 mg,
• In liver disease,
• In patients with very high levels of lipids in the blood(e.g., high cholesterol or triglycerides),
• In patients with very high levels of vitamin A in the body(hypervitaminosis A),
• During concurrent treatment with tetracyclines(an antibiotic used, for example, in the treatment of acne) (see "Other medicines and Izotek 20 mg").

In the event of any of the above situations, you should consult a doctor before starting treatment with Izotek 20 mg.

Warnings and precautions

Before starting treatment with Izotek 20 mg, you should discuss it with your doctor or pharmacist.

Pregnancy Prevention Program

IMPORTANT

Information for women

Pregnant women must not take Izotek 20 mg.

This medicine can seriously harm an unborn child(the medicine has a teratogenic effect). It can cause serious damage to the brain, face, ear, eye, heart, and some glands (thymus and parathyroid) of the fetus. It also increases the risk of miscarriage. These effects can occur even if Izotek 20 mg is taken for a short period during pregnancy.

• Do not take Izotek 20 mg if you are pregnant or think you may be pregnant.
• Do not take Izotek 20 mg during breastfeeding. The medicine is likely to pass into breast milk and may harm the breastfed child.
• Do not take Izotek 20 mg if you may become pregnant during treatment.
• Do not become pregnant for one month after stopping treatment with Izotek 20 mg, as the medicine may still be present in your body.

Izotek 20 mg may be prescribed to women of childbearing potential only under strict conditions

The following conditions must be met:

• The doctor must explain the risk of birth defects to the patient; the patient must understand why she must not become pregnant and how to prevent it.
• The patient must discuss contraception with her doctor. The doctor will provide information on contraceptive methods. The doctor may refer the patient to a specialist for advice on contraception.
• Before starting treatment, the doctor will ask the patient to have a pregnancy test. The test must show that the patient is not pregnant at the start of treatment with Izotek 20 mg.

Female patients must use effective contraception before, during, and after treatment with Izotek 20 mg.

• The patient must agree to use at least one highly effective method of contraception (e.g., an intrauterine device or contraceptive implant) or two effective methods that work in different ways (e.g., oral hormonal contraceptives and condoms). The patient should discuss with her doctor which methods are most suitable for her.
• The patient must use a contraceptive for one month before taking Izotek 20 mg

Izotek 20 mg, during treatment, and for one month after stopping the medicine.

• The patient must use contraception, even if she does not menstruate or is not currently sexually active(unless the doctor decides it is not necessary).

Female patients must agree to have pregnancy tests before, during, and after treatment with Izotek 20 mg.

• The patient must agree to have regular check-ups with her doctor, ideally every month.
• The patient must agree to have regular pregnancy tests, ideally every month during treatment and one month after stopping Izotek 20 mg, as the medicine may still be present in her body (unless the doctor decides it is not necessary for the individual patient).
• The patient must agree to have additional pregnancy testsas advised by her doctor.
• The patient must not become pregnant during and for one month after stopping treatment, as the medicine may still be present in her body.
• The doctor will discuss all these issues with the patient, using a checklist, and ask the patient (or her parent or legal guardian) to sign it. This form confirms that the patient has been informed of the risks and agrees to follow the above rules.

If the patient becomes pregnant while taking Izotek 20 mg, she must

stop taking the medicine immediatelyand contact her doctor. The doctor may refer the patient to a specialist for advice.

In addition, if the patient becomes pregnant within one month of stopping treatment with Izotek 20 mg, she should

contact her doctor. The doctor may refer the patient to a specialist for advice.

Advice for men

The amount of oral retinoids in the semen of men taking Izotek 20 mg is too small to harm an unborn child. However, this medicinal product should never be shared with anyone else, especially women.

Additional precautions

Never give this medicinal product to another person. All unused capsules should be returned to the pharmacist after treatment has ended.

Do not donate blood during treatment with this medicine or for one month after stopping Izotek 20 mg. If your blood is given to a pregnant woman, it may cause birth defects.

Information for all patients

• Tell your doctor if you have ever had mental health problems, including depression, aggression, or mood swings. This is because Izotek 20 mg may affect your mood. You may not notice certain changes in your mood and behavior, so it is very important that you tell your friends and family that you are taking this medicine. They may notice changes and help you identify problems that need to be discussed with your doctor.
• Severe skin reactions have been observed during treatment with isotretinoin(e.g., erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis). The rash can look like a widespread blistering or peeling of the skin. You should also look out for ulcers in the mouth, throat, nose, and genitals, as well as conjunctivitis (redness and swelling of the eyes).
• Izotek 20 mg can cause severe allergic reactions, which can include skin reactions such as rash, hives, and bruising or red and blue spots on the hands and feet. In case of an allergic reaction, you should stop taking Izotek 20 mg and contact your doctor immediately.
• Limit intense exercise and physical activity. Izotek 20 mg can cause muscle and joint pain, especially in children and adolescents who engage in intense physical activity.
• Isotretinoin has been associated with non-specific inflammatory bowel disease. If a patient has severe diarrhea with blood, and no history of gastrointestinal disease, the doctor will stop treatment with Izotek 20 mg.
• Izotek 20 mg may cause dry eye syndrome, intolerance to contact lenses, and vision problems, including impaired night vision. There have been cases of dry eye that did not improve after treatment ended. You should tell your doctor if you experience any of these symptoms. The doctor may recommend using moisturizing eye ointments or artificial tears. If you experience intolerance to contact lenses, the doctor may recommend wearing glasses during treatment. If you experience vision problems, the doctor may refer you to a specialist for advice and may recommend stopping Izotek 20 mg.
• Isotretinoin has been associated with mild increased intracranial pressure, especially when taken with tetracyclines (a type of antibiotic used, for example, in the treatment of acne). If you experience symptoms such as headache, nausea, vomiting, and vision disturbances, you should stop taking Izotek 20 mg and contact your doctor immediately. The doctor may refer you to a specialist to check for papilledema (swelling of the optic disc in the eye).
• Izotek 20 mg may increase liver enzyme activity. Your doctor will monitor liver enzyme activity with blood tests before, during, and after treatment. If liver enzyme activity remains high, your doctor may reduce the dose or stop treatment with Izotek 20 mg.
• Isotretinoin often leads to increased blood lipid levels, such as cholesterol or triglycerides. Your doctor will check your lipid levels before starting treatment with Izotek 20 mg, during treatment, and after treatment has ended. During treatment, it is best to avoid drinking alcohol or reduce the amount consumed. You should tell your doctor if you have high blood lipid levels, diabetes (high blood sugar), or if you are overweight or have a history of alcoholism. More frequent blood tests may be necessary. If your blood lipid levels remain high, your doctor may reduce the dose or stop treatment with Izotek 20 mg.

and if the patient experiences any problems with their nerves. The doctor may start treatment with a lower dose of Izotek 20 mg and then increase it to the maximum tolerated dose.

• Izotek 20 mg may increase blood sugar levels. In rare cases, patients have developed diabetes. Your doctor may monitor your blood sugar levels during treatment, especially if you already have diabetes or are overweight or have a history of alcoholism.
• It is likely that the skin will become dry. During treatment, you should use a moisturizing cream or lotion and lip balm to prevent dryness and irritation of the skin. To prevent skin irritation, you should avoid using exfoliating products or anti-acne treatments.
• Avoid excessive sun exposure and the use of sunlamps. Your skin may become more sensitive to sunlight. Before going out in the sun, you should apply a sunscreen with a high sun protection factor (at least SPF 15) to protect your skin.
• Do not have any cosmetic procedures on your skin. Izotek 20 mg can make your skin more sensitive. You should not wax, dermabrade, or have laser treatments (to remove dead skin or scars) during treatment and for at least 6 months after treatment has ended, as this can lead to scarring, skin irritation, and changes in skin color.
• Tell your doctor if you experience persistent back pain or pain in the buttocks. These symptoms may indicate inflammatory arthritis, a type of back pain caused by inflammation. Your doctor may stop treatment with Izotek 20 mg and refer you to a specialist for treatment of inflammatory back pain. Further evaluation, including imaging tests such as an MRI, may be necessary.

Children and adolescents

Izotek 20 mg is not recommended for children under 12 years of age. It is not known if the medicine is safe or effective in this age group.

Treatment with Izotek 20 mg in adolescents over 12 years of age is only possible after puberty.

Other medicines and Izotek 20 mg

Tell your doctor or pharmacist about all medicines you are taking, have recently taken, or might take, including those obtained without a prescription.

• Do not take vitamin A supplements or tetracyclines(an antibiotic used, for example, in the treatment of acne) or use any anti-acne treatments on your skin while taking Izotek 20 mg. You can use moisturizing products and emollients (creams or lotions applied to the skin to prevent water loss and soften the skin).
• While taking Izotek 20 mg, avoid using topical anti-acne keratolytic or exfoliating products.

Pregnancy and breastfeeding

If you are pregnant, breastfeeding, think you may be pregnant, or plan to have a baby, ask your doctor for advice before taking this medicine.
Pregnancy
Izotek 20 mg must not be used during pregnancy. If you are able to become pregnant, you must use effective contraception during treatment with Izotek 20 mg and for one month after stopping the medicine.
If you become pregnant during treatment with Izotek 20 mg or within one month of stopping treatment, you should stop taking the medicine immediatelyand contact your doctor. Your doctor may refer you to a specialist for advice.

Taking Izotek 20 mg during pregnancy may harm the unborn baby

(because the medicine has a teratogenic effect). It also increases the risk of miscarriage.

Izotek 20 mg may cause serious birth defects, including problems with the brain, face, ears, eyes, heart, and some glands (thymus and parathyroid) in the fetus

Do not take Izotek 20 mg during breastfeeding.It is likely that the medicine will pass into breast milk and may harm the breastfed child.
For more information on pregnancy and contraception, see section 2 "Pregnancy Prevention Program".

Driving and using machines

During treatment, your night vision may be impaired. Such vision disturbances can occur suddenly. In rare cases, they can persist after treatment has ended.
Very rarely, drowsiness, dizziness, and vision disturbances have been reported. If you experience these symptoms, you should not drive or operate machinery.

Izotek 20 mg contains soya oil

Do not take Izotek 20 mg if you are allergic to peanuts or soya.

3. How to take Izotek 20 mg

Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.

Recommended dose:

The initial dose is usually 0.5 mg per kilogram of body weight per day (0.5 mg/kg/day).
If your weight is 60 kg, treatment will usually start with a dose of 30 mg per day.

Capsules should be taken once or twice a day.

The medicine should be taken with food. Swallow the capsules whole with a drink of water or food.
After a few weeks, your doctor may change your dose. This depends on how you tolerate the treatment and the results. For most patients, the dose is between 0.5 mg/kg/day and 1 mg/kg/day.
If you feel that the effect of Izotek 20 mg is too weak or too strong, you should tell your doctor or pharmacist.
Treatment usually lasts from 16 to 24 weeks.In most patients, only one treatment cycle is needed. Acne symptoms may continue to improve for up to 8 weeks after treatment has ended. Treatment is usually not started again until then. Some people may experience worsening of acne during the first few weeks of treatment, but these symptoms should improve as treatment continues.

Patients with kidney problems

In cases of severe kidney disease, treatment should start with a lower dose (e.g., 10 mg/day), and the dose may be increased to the maximum tolerated dose.
If you do not tolerate the recommended dose, you may receive a lower dose, which may mean that treatment will be longer and that relapse of acne is more likely.

Taking more than the recommended dose of Izotek 20 mg

If you have taken too many capsules or if someone else has taken your medicine by mistake, you should contact your doctor, pharmacist, or the nearest hospital immediately.
Isotretinoin is a derivative of vitamin A. Symptoms of overdose with Izotek 20 mg are similar to those of vitamin A overdose. These include headache, nausea, vomiting, dizziness, irritability, and itching.

Missing a dose of Izotek 20 mg

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, do not take the missed dose, but continue treatment as prescribed. Do not take a double dose to make up for the missed dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, Izotek 20 mg can cause side effects, although not everybody gets them. These symptoms usually disappear or improve after stopping treatment. Others can be serious and require immediate medical attention.

Side effects that require immediate medical attention:

Skin problems

Frequency not known(frequency cannot be estimated from the available data)

• Severe skin rashes (erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), which can be life-threatening and require immediate medical attention. Initially, they may look like circular patches, often with central blisters, usually located on the hands and feet or buttocks. More severe rashes can spread to the chest and back. They can also be accompanied by additional symptoms such as eye infections (conjunctivitis) or ulcers in the mouth, throat, or nose. Some types of rash can look like widespread peeling of the skin, which can be life-threatening. The onset of these severe skin rashes is often preceded by headache, fever, and flu-like symptoms.

If you experience a severe rash or any of the above skin symptoms, you should stop taking Izotek 20 mg and contact your doctor immediately.

Psychiatric disorders

Rare side effects(may affect up to 1 in 1,000 people)

• Depression or related disorders. Symptoms include sadness, mood changes, anxiety, and emotional discomfort.
• Worsening of existing depression.
• Aggression or violent behavior.

Very rare side effects(may affect up to 1 in 10,000 people)

• Some people have had thoughts or ideas of self-harm or suicide (suicidal thoughts), attempted suicide (suicide attempts), or committed suicide. These people may not have shown symptoms of depression.
• Abnormal behavior.
• Psychotic symptoms: loss of contact with reality, e.g., the patient hears voices or sees things that do not exist.

If you experience any of the above psychiatric symptoms, you should

contact your doctor immediately.Your doctor may recommend stopping Izotek 20 mg. Stopping the medicine may not be enough to make these effects go away; additional help may be necessary, and your doctor can provide it.

Allergic reactions

Rare side effects(may affect up to 1 in 1,000 people)

• Severe (anaphylactic) reactions: difficulty breathing or swallowing due to sudden swelling of the throat, face, lips, and mouth. Also, sudden swelling of the hands, feet, and ankles.

Very rare side effects(may affect up to 1 in 10,000 people)

• Sudden chest tightness, shortness of breath, and wheezing, especially if you have asthma.

If you experience a severe allergic reaction, you should

go to the emergency department immediately.If you experience any allergic reaction, you should stop taking Izotek 20 mg and contact your doctor.

Musculoskeletal and connective tissue disorders

Frequency not known(frequency cannot be estimated from the available data)

• Muscle weakness, which can be life-threatening, may be associated with problems moving your arms or legs, pain, swelling, bruising, or discoloration of a part of your body, dark urine, decreased urine output, or feeling confused or dehydrated. These are symptoms of rhabdomyolysis, a breakdown of muscle tissue that can lead to kidney failure. This can happen if you engage in intense physical activity while taking Izotek 20 mg.

Disorders of the liver and bile ducts

Very rare side effects(may affect up to 1 in 10,000 people)
Jaundice or yellowing of the skin and eyes and feeling tired. These may be symptoms of liver inflammation.

You should stop taking Izotek 20 mg and contact your doctor immediately.

• Problems urinating, swollen and puffy eyelids, feeling very tired. These may be symptoms of kidney inflammation.

You should stop taking Izotek 20 mg and contact your doctor immediately.

Nervous system disorders

Very rare side effects(may affect up to 1 in 10,000 people)

• Persistent headache with nausea, vomiting, and vision disturbances, including blurred vision. These may be symptoms of mild increased intracranial pressure, especially when taken with tetracyclines (a type of antibiotic used, for example, in the treatment of acne).

You should stop taking Izotek 20 mg and contact your doctor immediately.

Gastrointestinal disorders

Very rare side effects(may affect up to 1 in 10,000 people)

• Severe abdominal pain with bloody diarrhea, nausea, and vomiting or without these symptoms. These may be symptoms of severe bowel disease.

You should stop taking Izotek 20 mg and contact your doctor immediately.

Eye disorders

Very rare side effects(may affect up to 1 in 10,000 people)

• Blurred vision.

If you experience blurred vision, you should

stop taking Izotek 20 mg and contact your doctor immediately.If you experience any other changes in your vision, you should contact your doctor as soon as possible.

Other side effects

Very common side effects(may affect more than 1 in 10 people)

• Dry skin, especially on the lips and face, skin inflammation, peeling, and inflammation of the lips, rash, mild itching, and mild peeling. From the start of treatment, you should use a moisturizing cream.
• Skin more sensitive and red than usual, especially on the face.
• Back pain, muscle pain, joint pain, especially in children and adolescents.
• Inflammation of the eyes (conjunctivitis) and eyelids, feeling of dryness and irritation of the eyes. You should ask your pharmacist for suitable eye drops.
• Increased liver enzyme activity in blood tests.
• Changes in blood lipid levels (including HDL or triglycerides).
• Bruising, bleeding, or faster blood clotting - if the problem affects the cells responsible for blood clotting.
• Anemia - weakness, dizziness, paleness - if the problem affects red blood cells.

Common side effects(may affect up to 1 in 10 people)

• Headache.
• High cholesterol levels in the blood.
• Presence of protein or blood in the urine.
• Increased susceptibility to infections, if the problem affects white blood cells.
• Dryness of the nasal passages and formation of crusts, leading to mild nosebleeds.
• Pain or inflammation of the throat and nasal passages.
• Allergic reactions, such as rash, itching. If you experience any allergic reaction, you should stop taking Izotek 20 mg and contact your doctor.

Rare side effects(may affect up to 1 in 1,000 people)

• Hair loss (alopecia). This is usually temporary and should stop after treatment has ended.

Very rare side effects(may affect up to 1 in 10,000 people)

• Impaired night vision, color blindness, and other vision problems.
• Increased sensitivity to light; you may need to wear sunglasses to protect your eyes from too much light.
• Other vision problems, including blurred vision, distorted vision, and clouding of the cornea (corneal clouding, cataract).
• Excessive thirst, need to urinate frequently, blood test results showing high blood sugar levels. These may be symptoms of diabetes.
• During the first few weeks, acne may worsen, but symptoms should start to improve as treatment continues.
• Skin inflammation, swollen and darker than usual, especially on the face.
• Excessive sweating or itching.
• Arthritis; bone problems (delayed growth, excessive growth, and changes in bone density); growth arrest may occur in growing bones.
• Calcification of soft tissues; pain in tendons; high levels of muscle breakdown products in the blood, especially with intense physical activity.
• Increased sensitivity to light.
• Bacterial infections at the base of the nails, changes in the nails.
• Swelling, discharge, pus.
• Excessive scarring after surgery.
• Increased hair growth on the body.
• Seizures, drowsiness, dizziness.
• Swollen lymph nodes.
• Dry throat, hoarseness.
• Hearing problems.
• General feeling of being unwell.
• High levels of uric acid in the blood.
• Bacterial infections.
• Vasculitis (sometimes with bruising or red and blue spots).

Frequency not known(frequency cannot be estimated from the available data)

• Dark or dark brown urine.
• Difficulty achieving or maintaining an erection.
• Reduced sex drive.
• Breast tenderness or swelling, occurring in men
• Vaginal dryness.
• Inflammatory arthritis, a type of back pain caused by inflammation, causing pain in the lower back or buttocks.
• Urethritis.

Reporting side effects

If you experience any side effects, including those not listed in this leaflet, you should tell your doctor or pharmacist. Side effects can be reported directly to the Department of Drug Safety, Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, Al. Jerozolimskie 181C, 02-222 Warszawa, tel.: +48 22 49 21 301, fax: +48 22 49 21 309, website: https://smz.ezdrowie.gov.pl
By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Izotek 20 mg

Keep this medicine out of the sight and reach of children.
Do not store above 25°C. Store in the original package.
Keep the package tightly closed to protect from light.
Do not use this medicine after the expiry date stated on the package. The expiry date refers to the last day of the month stated.
Return any remaining capsules to the pharmacist.Only keep them if your doctor advises you to.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

What Izotek 20 mg contains

• The active substance of Izotek 20 mg is isotretinoin. Izotek 20 mg: each soft capsule contains 20 mg of isotretinoin.
• The other ingredients are purified soya oil, yellow wax, hydrogenated soya oil, and partially hydrogenated vegetable oil.
• Cap: gelatin, glycerol, titanium dioxide (E 171), iron oxide red (E 172), iron oxide yellow (E 172).

What Izotek 20 mg looks like and contents of the pack

Izotek 20 mg are oval, red-orange capsules (size 6).
The medicine is available in cardboard boxes containing blisters of PVC/PE/PVDC/Aluminum.
For more detailed information, please contact the marketing authorization holder or the parallel importer.

Marketing authorization holder in Greece, the country of export:

Pharmathen Investments Group Limited
Kritis 32, Papachristoforou Building, 4th floor
3087 Lemesos
Cyprus

Manufacturer:

Pharmathen S.A.
6, Dervenakion Str.
153 51 Pallini
Athens, Greece
Pharmathen International S.A.
Industrial Park Sapes, Block No 5
Rodopi Prefecture 69300, Greece

Parallel importer:

Medezin Sp. z o.o.
ul. Zbąszyńska 3
91-342 Łódź

Repackaged by:

Medezin Sp. z o.o.
ul. Zbąszyńska 3
91-342 Łódź
CEFEA Sp. z o.o. Sp. komandytowa
ul. Działkowa 56
02-234 Warszawa
Pharma Innovations Sp. z o.o.
ul. Jagiellońska 76
03-301 Warszawa
Synoptis Industrial Sp. z o.o.
ul. Szosa Bydgoska 58
87-100 Toruń
CANPOLAND SPÓŁKA AKCYJNA
ul. Beskidzka 190
91-610 Łódź
Marketing authorization number in Greece, the country of export:45047/10/18-04-2012
Parallel import authorization number:240/22

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

Denmark:
Isotretinoin Orion
Finland:
Isotretinoin Orion
Poland:
Izotek
Greece:
A-Cnotren 20 mg

Date of revision of the leaflet: 16.05.2024

[Information about the trademark]
Detailed and up-to-date information about this medicine is available by scanning the QR code on the leaflet using a smartphone. The same information is also available on the website http://sirpl.org/Retinoidy
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