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Histigen

Ask a doctor about a prescription for Histigen

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Histigen

Package Leaflet: Information for the User

Histigen, 8 mg, Tablets

Histigen, 16 mg, Tablets

(Betahistini dihydrochloridum)

Important: Read the Package Leaflet Carefully Before Taking the Medication

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, including those not listed in this leaflet, tell your doctor or pharmacist. See section 4.

Table of Contents of the Package Leaflet:

  • 1. What is Histigen and what is it used for
  • 2. Important information before taking Histigen
  • 3. How to take Histigen
  • 4. Possible side effects
  • 5. How to store Histigen
  • 6. Contents of the pack and other information

1.

What is Histigen and what is it used for

Histigen contains betahistine, which belongs to a group of medications used to treat vertigo.
This medication is indicated for the treatment of certain types of vertigo.

2. Important information before taking Histigen

When not to take Histigen

  • if you are allergic to the active substance or any of the other ingredients of this medication (listed in section 6);
  • if your doctor has diagnosed you with a pheochromocytoma, a tumor of the adrenal gland that can cause high blood pressure.

Warnings and precautions

Special warnings

If you have asthma, you should discuss this with your doctor or pharmacist before taking Histigen.
In such cases, patients taking Histigen should be closely monitored due to the risk of bronchospasm.
Patient with a history of peptic ulcer or who have had a peptic ulcer in the past should also be closely monitored during treatment.
Histigen should not be used to treat the following types of vertigo:

  • mild positional vertigo,
  • vertigo associated with central nervous system disorders.

Taking the medication with meals may help reduce gastrointestinal upset.
Before taking the medication, consult your doctor or pharmacist.

Histigen and other medications

Tell your doctor or pharmacist about all medications you are currently taking or have recently taken, as well as any medications you plan to take.
In particular, inform your doctor or pharmacist if you are taking any of the following medications:

  • antihistamines, which may reduce the effect of betahistine. Betahistine may also reduce the effect of antihistamines.
  • monoamine oxidase inhibitors, used to treat Parkinson's disease. They may increase the effect of Histigen.

Pregnancy, breastfeeding, and fertility

Do not take Histigen during pregnancy, unless your doctor has decided that it is necessary.
If you become pregnant during treatment, consult your doctor, as they can assess whether it is necessary to continue treatment.
If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, consult your doctor or pharmacist before taking this medication.

Driving and using machines

Histigen is unlikely to affect your ability to drive or use machines.

3. How to take Histigen

Always take this medication exactly as your doctor has told you.
If you are unsure, consult your doctor or pharmacist.
Dosage
The usual dose is 1 to 2 tablets three times a day. Do not take more than 6 tablets per day.
Caution is advised when administering this medication to elderly patients.
Use in children and adolescents:
Betahistine is not recommended for children and adolescents under 18 years of age.
Method of administration
Oral use.
Take the medication orally during meals to avoid stomach upset.
Swallow the tablet with a glass of water. Do not chew.
If you feel that the effect of Histigen is too strong or too weak, consult your doctor.

Overdose of Histigen

If you have taken too much of this medication (overdose), contact your doctor or go to the hospital immediately.

Missing a dose of Histigen

If you miss a dose, take the next dose at the scheduled time. Do not take a double dose to make up for the missed dose.
If you have any further questions about the use of this medication, consult your doctor or pharmacist.

4. Possible side effects

Like all medications, Histigen can cause side effects, although not everybody gets them.
Common side effects (occurring in 1 to 10 users in 100):

  • nausea
  • gastrointestinal disorders
  • headache

Frequency not known (frequency cannot be estimated from the available data):

  • marked decrease in platelet count
  • allergic reactions, which may include symptoms such as facial, lip, tongue, or throat swelling, causing difficulty breathing (anaphylactic reaction)
  • mild gastrointestinal upset, such as vomiting, dry mouth, diarrhea, abdominal pain, bloating, and gas. These side effects can be avoided by taking the tablet during meals or reducing the dose of the medication.
  • skin allergic reactions, in particular anaphylactic reaction, rash, redness, itching

Reporting side effects

If you experience any side effects, including those not listed in this leaflet, tell your doctor or pharmacist.
Side effects can be reported directly to the Department of Post-Marketing Surveillance of Adverse Reactions to Medicinal Products, Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products,
Al. Jerozolimskie 181C,
02-222 Warsaw,
tel.: +48 22 49 21 301,
fax: +48 22 49 21 309,
website: https://smz.ezdrowie.gov.pl.
Reporting side effects will help to gather more information on the safety of this medication.

5. How to store Histigen

Keep this medication out of the sight and reach of children.
Do not use this medication after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month.
There are no special precautions for storage.
Medications should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medications no longer required. This will help protect the environment.

6. Contents of the pack and other information

What Histigen contains

  • The active substance is betahistine dihydrochloride (Betahistini dihydrochloridum).
  • The other ingredients are: microcrystalline cellulose, mannitol, citric acid monohydrate, colloidal anhydrous silica, talc.

What Histigen looks like and contents of the pack

Histigen 8 mg is a white or almost white, round tablet with a diameter of about 7 mm, with a score line and marked "256" on one side.
Histigen 16 mg is a white or almost white, round, biconvex tablet with a score line and marked "267" on both sides of the score line on one side. The diameter of the tablet is about 8.5 mm.
Pack sizes:
PVC/PVDC-Aluminum blisters in a cardboard box containing 30, 60, or 100 tablets.
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder
Viatris Limited
Damastown Industrial Park
Mulhuddart, Dublin 15
DUBLIN
Ireland
Manufacturer
Mylan Laboratories SAS
Route de Belleville
Lieu-dit Maillard
01400 Châtillon-sur-Chalaronne
France
For further information, please contact the marketing authorization holder's representative:

Viatris Healthcare Sp. z o.o.

Tel. +48 22 54 66 400

Date of last revision of the package leaflet:

Alternatives to Histigen in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Histigen in Spain

Dosage form: TABLET, 8 mg
Active substance: betahistine
Manufacturer: Laboratorio Stada S.L.
Prescription required
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Active substance: betahistine
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Active substance: betahistine
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Dosage form: TABLET, 16 mg
Active substance: betahistine
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Alternative to Histigen in Ukraine

Dosage form: tablets, tablets 8mg
Active substance: betahistine
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Dosage form: tablets, tablets 24mg
Active substance: betahistine
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Active substance: betahistine
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Active substance: betahistine
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Active substance: betahistine
Manufacturer: TOV "Farmeks Grup
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