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Enterol

Enterol

Ask a doctor about a prescription for Enterol

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Enterol

Leaflet attached to the packaging: patient information

Warning! Keep the leaflet! Information on the immediate packaging in a foreign language.

Enterol

250 mg, powder for oral suspension

Saccharomyces boulardiiCNCM I-745

You should carefully read the contents of the leaflet before using the medicine, as it contains important information for the patient.

This medicine should always be taken exactly as described in this patient leaflet or as directed by your doctor or pharmacist.

  • You should keep this leaflet, so you can read it again if you need to.
  • If you need advice or additional information, you should consult a pharmacist.
  • If the patient experiences any side effects, including any possible side effects not listed in the leaflet, they should tell their doctor, pharmacist, or nurse. See section 4.
  • If there is no improvement after 2 days or the patient feels worse, they should contact their doctor.

Table of contents of the leaflet:

  • 1. What is Enterol and what is it used for
  • 2. Important information before taking Enterol
  • 3. How to take Enterol
  • 4. Possible side effects
  • 5. How to store Enterol
  • 6. Contents of the packaging and other information

1. What is Enterol and what is it used for

Enterol is an oral anti-diarrheal medicine, whose active substance is lyophilized Saccharomyces boulardiiyeast, classified as probiotics, i.e., living microorganisms that bring health benefits to the host organism.
The intestinal bacterial flora consists of billions of microorganisms. Maintaining the balance of the intestinal microflora is necessary to ensure the essential functions of the digestive tract, such as:
digestion, resistance to infections, and strengthening the natural immune system.
The balance of the bacterial flora is delicate and can be disrupted by many factors:
digestive tract infections, both viral and bacterial, taking certain medications, including antibiotics, changes in dietary habits. This can cause a range of digestive problems leading to diarrhea.
Enterol is a medicine that affects the intestinal flora, a so-called "substitute for natural flora," which allows for the balancing of its temporary disruption.
Enterol is used in:

  • treatment of acute infectious diarrhea
  • prevention of antibiotic-associated diarrhea
  • recurrent diarrhea caused by Clostridium difficileinfection, as an adjunct to treatment with vancomycin or metronidazole
  • prevention of diarrhea associated with enteral nutrition
  • prevention of traveler's diarrhea
  • supportive treatment of diarrhea occurring in irritable bowel syndrome (IBS).

If there is no improvement after 2 days or the patient feels worse, they should consult their doctor.

2. Important information before taking Enterol

When not to take Enterol

  • if the patient is allergic to the active substance or any of the other ingredients of this medicine (listed in section 6)
  • if the patient has a central venous catheter (see section "Warnings and precautions")
  • in patients with significantly reduced immunity or hospitalized (due to severe illness or immune system disorders).

Warnings and precautions

Before starting to take Enterol, you should discuss it with your doctor.
It is not recommended to open sachets near patients with a central venous catheter to prevent unwanted fungal colonization of the catheter, especially through contaminated hands. There have been reports of very rare cases of fungemia (fungal penetration into the blood) with accompanying fever and positive blood culture results, even in patients not treated with Saccharomyces boulardii. In all reported cases, fungemia resolved after antifungal treatment or, when necessary, after removal of the central venous catheter.
As a supplement to treatment, it is recommended:

  • adequate hydration of the body (rehydration) by consuming large amounts of salty or sweet drinks to compensate for fluid loss due to diarrhea (the average daily water requirement for an adult is 2 liters)
  • maintaining an appropriate dietary regimen, excluding certain foods, such as fruits, green vegetables, spicy dishes, frozen food, and chilled drinks; however, it is recommended to consume grilled meat and rice; it is advisable to consider limiting the consumption of milk and dairy products.

You should immediately consult a doctor if:

  • there is no improvement after 2 days of treatment
  • there is a fever, vomiting
  • blood or mucus appears in the stool
  • there is a feeling of increased thirst, dryness of the tongue: these are symptoms of beginning dehydration, i.e., loss of a significant amount of fluid due to diarrhea. You should contact a doctor who will decide on the need for oral or intravenous rehydration.

Enterol and other medicines

You should tell your doctor or pharmacist about all medicines you are currently taking or have recently taken, as well as any medicines you plan to take.
You should not take Enterol at the same time as oral antifungal medicines (medicines used to treat fungal infections).

Enterol with food, drink, and alcohol

Enterol contains live cells. For this reason, it should not be mixed with very hot (above 50°C) or cold liquids, foods, or alcohol, as this could destroy the yeast cells.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, you should consult your doctor or pharmacist before taking this medicine.
Due to the lack of data, it is not recommended to use the medicine during pregnancy.
Saccharomyces boulardiiis not absorbed into breast milk. Due to the lack of data, it is recommended to consider the benefit-risk ratio before taking Enterol during breastfeeding.

Driving and using machines

The medicine does not affect driving or using machines.

Enterol contains fructose

One sachet of the medicine contains 471.90 mg of fructose.
In case of frequent use of this medicine or use for a long time (e.g., for two weeks), fructose may have a harmful effect on teeth.
If you have previously been diagnosed with intolerance to some sugars or have a rare genetic disease where your body does not break down fructose, you should consult your doctor before taking the medicine or giving it to your child.

Enterol contains lactose monohydrate.

If you have previously been diagnosed with intolerance to some sugars, you should consult your doctor before taking the medicine.

The medicine contains sorbitol (E 420)

One sachet of the medicine contains 0.10 mg of sorbitol (E 420).

Enterol contains glucose

  • If you have previously been diagnosed with intolerance to some sugars, you should consult your doctor before taking the medicine.
  • It may have a harmful effect on teeth.

3. How to take Enterol

This medicine should always be taken exactly as described in this patient leaflet or as directed by your doctor or pharmacist. If you have any doubts, you should consult your doctor or pharmacist.
Recommended dosage for adults and children:
acute infectious diarrhea: 1 to 2 sachets per day for up to 1 week
antibiotic-associated diarrhea: 1 to 2 sachets per day, during and after antibiotic therapy
diarrhea caused by C. difficileinfection: 4 sachets per day for up to 4 weeks
diarrhea associated with enteral nutrition: 1 to 2 sachets per day
traveler's diarrhea: 1 to 4 sachets per day for up to 1 week
supportive treatment of diarrhea occurring in irritable bowel syndrome (IBS): 1 sachet 1 to 2 times a day. Diarrhea treatment should be continued for several days after symptoms resolve.
Method of administration:
Take orally.
The contents of the sachet should be added to a small amount of water or a sweetened drink, mixed, and drunk. The powder from the sachet can also be mixed with food or added to a bottle of food for a child. Do not mix with liquids or foods that are too hot (above 50°C), frozen, or contain alcohol.

Missing a dose of Enterol

You should not take a double dose to make up for a missed dose.
If you have any further doubts about taking this medicine, you should consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Rare (occurring in less than 1 in 1000): a few cases of bloating have been reported.
Very rare (occurring in less than 1 in 10,000): local rash, allergic reactions, hives, itching, anaphylactic reactions, facial swelling, angioedema, rash on the whole body (exanthema), fungal penetration into the blood (fungemia).
Frequency not known: (frequency cannot be estimated from the available data): constipation, severe blood infection (sepsis).

Reporting side effects

If you experience any side effects, including any possible side effects not listed in the leaflet, you should tell your doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products, Al. Jerozolimskie 181C, 02-222 Warsaw, tel.: +48 22 49 21 301, fax: +48 22 49 21 309, website: https://smz.ezdrowie.gov.pl.
By reporting side effects, you can help gather more information on the safety of the medicine.

5. How to store Enterol

Do not store above 25°C.
Store in the original packaging to protect from moisture.
The medicine should be stored out of sight and reach of children.
Do not use this medicine after the expiry date stated on the packaging. The expiry date refers to the last day of the given month.
Medicines should not be disposed of via wastewater or household waste containers. You should ask your pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. Contents of the packaging and other information

What Enterol contains

  • The active substance of the medicine is lyophilized Saccharomyces boulardiiyeast, CNCM I-745, one sachet contains 250 mg of yeast.
  • The other ingredients are: lactose monohydrate, fructose, colloidal silica anhydrous (Aerosil 200), fruit flavor (containing sorbitol (E 420)).

What Enterol looks like and what the packaging contains

The packaging contains 10 or 20 sachets.
For more detailed information, you should contact the marketing authorization holder or parallel importer.

Marketing authorization holder in Latvia, the country of export:

Biocodex
22 rue des Aqueducs
94250 Gentilly
France

Manufacturer:

Biocodex
1 avenue Blaise Pascal
60000 Beauvais
France

Parallel importer:

InPharm Sp. z o.o.
ul. Strumykowa 28/11
03-138 Warsaw

Repackaged by:

InPharm Sp. z o.o. Services sp. k.
ul. Chełmżyńska 249
04-458 Warsaw
Marketing authorization number in Latvia, the country of export:97-0021

Parallel import authorization number: 131/25

Date of leaflet approval: 07.04.2025

[Information about the trademark]

  • Country of registration
  • Active substance
  • Prescription required
    No
  • Marketing authorisation holder (MAH)
    Biocodex
  • Alternatives to Enterol
    Dosage form: Powder, 500 mg
    Active substance: saccharomyces boulardii
    Manufacturer: Biocodex
    Prescription not required
    Dosage form: Capsules, 250 mg
    Active substance: saccharomyces boulardii
    Prescription not required
    Dosage form: Capsules, 250 mg
    Active substance: saccharomyces boulardii
    Prescription not required

Alternatives to Enterol in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Enterol in Spain

Dosage form: ORAL SOLUTION/SUSPENSION, 250 mg
Active substance: saccharomyces boulardii
Manufacturer: Biocodex
Prescription not required
Dosage form: CAPSULE, 50 mg
Active substance: saccharomyces boulardii
Manufacturer: Biocodex
Prescription not required
Dosage form: ORAL SOLUTION/SUSPENSION, 250 mg
Active substance: saccharomyces boulardii
Manufacturer: Biocodex
Prescription not required
Dosage form: CAPSULE, 250 mg
Active substance: saccharomyces boulardii
Manufacturer: Biocodex
Prescription not required
Dosage form: ORAL SOLUTION/SUSPENSION, 120 MILLION GERMS
Manufacturer: Casen Recordati S.L.
Prescription not required

Alternative to Enterol in Ukraine

Dosage form: capsules, 10 capsules in a blister
Active substance: saccharomyces boulardii
Manufacturer: Ardejfarm GmbH
Prescription not required
Dosage form: powder, 250mg
Active substance: saccharomyces boulardii
Manufacturer: BIOKODEKS
Prescription not required
Dosage form: capsules, 250 mg
Active substance: saccharomyces boulardii
Manufacturer: BIOKODEKS
Prescription not required
Dosage form: capsules, 250 mg
Active substance: saccharomyces boulardii
Manufacturer: ABELA FARM DOO BELGRAD
Prescription not required
Dosage form: suspension, 1 ml in a polyethylene ampoule
Manufacturer: Ardejfarm GmbH
Prescription required
Dosage form: suspension, 5 ml in a vial
Prescription not required

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