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Diphergan

Ask a doctor about a prescription for Diphergan

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Doctor

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Diphergan

Package Leaflet: Information for the Patient

DIPHERGAN, 25 mg, effervescent tablets

Promethazine hydrochloride

Read the package leaflet carefully before taking the medicine, as it contains important information for the patient.

  • Keep this leaflet, you may need to read it again.
  • In case of any doubts, consult a doctor, pharmacist, or nurse.
  • This medicine has been prescribed specifically for you. Do not pass it on to others.
  • The medicine may harm another person, even if their symptoms are the same.
  • If the patient experiences any side effects, including any not listed in this leaflet, they should inform their doctor, pharmacist, or nurse. See section 4.

Table of Contents of the Leaflet

  • 1. What is Diphergan and what is it used for
  • 2. Important information before taking Diphergan
  • 3. How to take Diphergan
  • 4. Possible side effects
  • 5. How to store Diphergan
  • 6. Package contents and other information

1. What is Diphergan and what is it used for

Diphergan is a strong antihistamine with a long duration of action, also exhibiting sedative and antiemetic effects.
The medicine is used:

  • for symptomatic treatment of allergic conditions of the upper respiratory tract and skin, including allergic rhinitis, urticaria, and anaphylactic reactions to drugs and foreign proteins;
  • as an adjunct to preoperative sedation of patients in surgery and obstetrics;
  • as an antiemetic, e.g., in kinetosis (motion sickness).

2. Important information before taking Diphergan

When not to take Diphergan

  • if the patient is allergic to promethazine or other phenothiazine derivatives, or any of the other ingredients of this medicine (listed in section 6);
  • if the patient is in a coma;
  • if the patient has central nervous system depression, regardless of its cause;
  • if the patient is being treated with monoamine oxidase inhibitors (MAOIs) and for 14 days after stopping MAOIs;
  • in children under 2 years of age.

Warnings and precautions

Before starting treatment with Diphergan, consult a doctor or nurse if:

  • the patient has any serious heart problems
  • the patient has a history of heart disease
  • the patient has an irregular heart rhythm. Inform the doctor about the following cases that affect the safety of the patient taking Diphergan:
  • pregnancy;
  • breastfeeding;
  • asthma, bronchitis, or bronchiectasis, severe coronary artery disease;
  • epilepsy;
  • renal or hepatic insufficiency;
  • glaucoma with a narrow angle of filtration (increased intraocular pressure);
  • prostatic hyperplasia;
  • difficulty urinating or gastric obstruction;
  • symptoms indicating Reye's syndrome in children and adolescents (diarrhea, rapid breathing, vomiting, fever, seizures).

The medicine may cause allergic reactions.
During treatment with Diphergan, avoid direct sun exposure.

Diphergan and other medicines

Inform the doctor or pharmacist about all medicines currently being taken or recently taken, as well as any medicines the patient plans to take.
Also, inform the doctor or pharmacist about any of the following medicines being taken:

  • medicines that may affect heart rhythm.

Do not take Diphergan with monoamine oxidase inhibitors (MAOIs) or for 14 days after stopping MAOIs.
Diphergan enhances the effects of anticholinergic, tricyclic antidepressant, sedative, or hypnotic medicines.

Diphergan and alcohol

Do not drink alcohol while taking Diphergan.

Pregnancy, breastfeeding, and fertility

In pregnancy, during breastfeeding, or if pregnancy is suspected, or if the patient is planning to become pregnant, consult a doctor before taking this medicine.
Pregnancy
Diphergan should only be used during pregnancy under medical supervision. It is not recommended to use Diphergan during the last 2 weeks before the planned delivery date.
Breastfeeding
Diphergan can be used during breastfeeding only under medical supervision.

Driving and operating machinery

Do not drive or operate machinery, as the medicine may cause drowsiness, dizziness, and disorientation.
These symptoms occur most frequently during the first few days of treatment.

Diphergan contains lactose and sucrose

If the patient has previously been diagnosed with intolerance to some sugars, they should consult a doctor before taking the medicine.

Diphergan contains cochineal red (E 124)

The medicine may cause allergic reactions.

Diphergan contains sodium

The medicine contains less than 1 mmol (23 mg) of sodium per effervescent tablet, which means it is considered "sodium-free".

3. How to take Diphergan

Always take this medicine exactly as prescribed by the doctor. In case of doubts, consult a doctor or pharmacist.
The doctor will adjust the dosage individually for each patient, depending on the indications, the patient's age, and their sensitivity to the medicine.

Recommended dose

In allergic reactions:

  • adults, including the elderly, and children over 10 years: 25 mg once a day (preferably at night), increasing to a maximum of 25 mg twice a day if necessary;
  • children from 5 to 10 years: 10 to 25 mg once (preferably at night) or 5 to 10 mg twice a day, up to a maximum of 25 mg per day;

In preventing motion sickness:

  • adults, including the elderly, and children over 10 years: 25 mg at night before the trip; if necessary, the dose can be repeated after 6-8 hours;

In preparing the patient for surgery:

  • adults and children over 10 years: 25 to 50 mg 1 hour before the procedure;
  • children from 5 to 10 years: 25 mg 1 hour before the procedure.

Use in children and adolescents

Do not use in children under 2 years of age.
Use in children from 2 to 5 years: use Diphergan in the form of syrup.
Use in children from 5 years: use in the form of effervescent tablets (see above).

Taking a higher dose of Diphergan than recommended

In case of taking too high a dose, immediately contact a doctor or go to the emergency room at the nearest hospital.

Missing a dose of Diphergan

If a dose is missed:

  • in the treatment of allergies, take it as soon as possible and continue with the previous dosage;
  • in cases of restlessness and insomnia, omit this dose and take the next one the following evening; Do not take a double dose to make up for the missed dose.

Stopping treatment with Diphergan

In case of any further doubts about taking this medicine, consult a doctor, pharmacist, or nurse.

4. Possible side effects

Like all medicines, Diphergan can cause side effects, although not everybody gets them.
Nervous system disorders:

  • drowsiness, dizziness, and headaches, nightmares, fatigue, and disorientation, confusion, extrapyramidal reactions.
  • restlessness, severe reaction with fever, muscle stiffness, blood pressure changes, and coma (malignant neuroleptic syndrome) - frequency not known (cannot be estimated from the available data).

Eye disorders:

  • vision disturbances.

Gastrointestinal disorders:

  • dry mouth, stomach irritation.

Renal and urinary disorders:

  • urinary retention.

Metabolic and nutritional disorders:

  • anorexia.

Cardiac disorders:

  • palpitations, low blood pressure (hypotension), arrhythmia.
  • abnormal heart electrical activity affecting heart rhythm, including life-threatening arrhythmias - frequency not known (cannot be estimated from the available data).

Musculoskeletal and connective tissue disorders:

  • muscle cramps and movements of the head and face resembling tics.

Immune system disorders:

  • anaphylaxis, photosensitivity reactions have been reported, avoid strong sunlight during treatment.

Blood and lymphatic system disorders:

  • abnormal blood counts, including hemolytic anemia.
  • low platelet count (which may lead to bleeding and bruising) - frequency not known (cannot be estimated from the available data).

Hepatobiliary disorders:

  • jaundice.

Psychiatric disorders:

  • hallucinations, aggression - frequency not known (cannot be estimated from the available data).

Infants are susceptible to the anticholinergic effects of promethazine, while older children may exhibit paradoxical hyperactivity.
The elderly are particularly susceptible to the anticholinergic effects and confusion caused by promethazine.
Side effects are usually mild and do not require discontinuation of treatment. Some of them may disappear on their own over time.
Diagnostic tests
Diphergan may affect the results of pregnancy tests and skin tests.

Reporting side effects

If any side effects occur, including any not listed in the leaflet, inform the doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products
Aleje Jerozolimskie 181C
02-222 Warsaw
Phone: +48 22 49 21 301
Fax: +48 22 49 21 309
Website: https://smz.ezdrowie.gov.pl
Side effects can also be reported to the marketing authorization holder.
Reporting side effects will help to gather more information on the safety of the medicine.

5. How to store Diphergan

Keep the medicine out of sight and reach of children.
Store in a temperature below 25°C. Store in the original packaging to protect from light and moisture.
Do not use this medicine after the expiry date stated on the carton.
The expiry date refers to the last day of the month.
Medicines should not be disposed of via wastewater or household waste. Ask the pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package contents and other information

What Diphergan contains

The active substance of the medicine is promethazine hydrochloride. One effervescent tablet contains 25 mg of promethazine hydrochloride.
The other ingredients are:

  • effervescent tablet core: lactose monohydrate, potato starch, sucrose, gelatin, talc, sodium saccharin, magnesium stearate.
  • effervescent tablet coating: sucrose, talc, gum arabic, cochineal red (E 124), Capol 1295 (a mixture of carnauba wax and beeswax).

What Diphergan looks like and what the package contains

Diphergan 25 mg are red effervescent tablets.
The package contains 20 tablets.

Marketing authorization holder

Bausch Health Ireland Limited
3013 Lake Drive
Citywest Business Campus
Dublin 24, D24PPT3
Ireland

Manufacturer

Przedsiębiorstwo Farmaceutyczne Jelfa SA
58-500 Jelenia Góra, ul. Wincentego Pola 21
Date of last revision of the leaflet:March 2025

Alternatives to Diphergan in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Diphergan in Hiszpania

Dosage form: ROZTWÓR/ZAWIESINA DOUSTNA, KROPLE, 5 g
Active substance: alimemazine
Prescription required

Online doctors for Diphergan

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Diphergan – subject to medical assessment and local rules.

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Maryna Kuznetsova

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Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
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Doctor

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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She treats adults with respiratory illnesses such as pneumonia, COPD and bronchial asthma, as well as cardiovascular conditions including hypertension and ischaemic heart disease. Her practice also covers gastrointestinal complaints and chronic comorbidities that require careful, structured medical supervision.

Dr Boichuk provides care for children from birth, including acute respiratory viral infections, infectious diseases, pneumonia, bronchitis, bronchial obstruction syndromes and allergic reactions. She offers clear, evidence-based guidance to parents and ensures safe follow-up throughout the child’s recovery.

Her work also includes developing personalised immunisation plans and supporting families with long-term preventive care.

Known for her structured clinical approach and clear communication, Dr Liudmyla Boichuk offers patients of all ages comprehensive, reliable and evidence-based medical care.

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Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Mar Tabeshadze

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Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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  • Chronic conditions: hypertension, diabetes, metabolic disorders.
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  • Routine health check-ups, prevention of cardiovascular and metabolic diseases.
  • Personalised nutritional advice to improve hair strength, skin health, and hormonal balance.
  • Aesthetic medicine: non-invasive strategies to enhance skin quality, tone, and metabolic wellness.

Dr Alexandrova follows an evidence-based and holistic approach: online consultations with a therapist and trichologist on Oladoctor provide professional support for hair, scalp, and overall health — all from the comfort of your home.

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