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Depremin 612 mg

Depremin 612 mg

Ask a doctor about a prescription for Depremin 612 mg

5.0(25)
Doctor

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Depremin 612 mg

Package Leaflet: Information for the Patient

Depremin 612mg, 612 mg, Coated Tablets

Hyperici herbae extractum siccum quantificatum

Read the package leaflet carefully before taking the medicine, as it contains

important information for the patient.
This medicine should always be taken exactly as described in the package leaflet or as directed by your doctor or pharmacist.

  • The package leaflet should be kept in case it needs to be read again.
  • If advice or additional information is needed, you should consult a pharmacist.
  • If the patient experiences any side effects, including any possible side effects not listed in the package leaflet, they should inform their doctor or pharmacist. See section 4.
  • If there is no improvement after 4 weeks or the patient feels worse, they should contact their doctor.

Table of Contents of the Package Leaflet

  • 1. What is Depremin 612mg and what is it used for
  • 2. Important information before taking Depremin 612mg
  • 3. How to take Depremin 612mg
  • 4. Possible side effects
  • 5. How to store Depremin 612mg
  • 6. Contents of the pack and other information

1. What is Depremin 612mg and what is it used for

A herbal medicinal product for the short-term treatment of mild depressive symptoms.
If there is no improvement after 4 weeks or the patient feels worse, they should consult their doctor.

2. Important information before taking Depremin 612mg

When not to take Depremin 612mg:

  • if the patient is allergic to the active substance or any of the other ingredients of this medicine (listed in section 6).
  • if the patient is taking medicines that reduce the rejection of transplanted organs: cyclosporine, systemic tacrolimus, medicines used to treat HIV infection: amprenavir, indinavir, and other protease inhibitors, anticancer medicines: irinotecan, and anticoagulant medicines: warfarin.

Warnings and precautions

Before starting treatment with Depremin 612mg, the patient should discuss it with their doctor or pharmacist.
During treatment, the patient should avoid exposure to intense UV radiation (ultraviolet).

Children and adolescents

Due to the lack of sufficient data, the use of Depremin 612mg in children and adolescents under 18 years of age is not recommended.

Depremin 612mg and other medicines

The patient should inform their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
St. John's Wort extract induces the activity of CYP3A4, CYP2C9, CYP2C19, and P-glycoprotein enzymes.
Concomitant use of cyclosporine, systemic tacrolimus (medicines that reduce the rejection of transplanted organs), amprenavir, indinavir, and other protease inhibitors (medicines used to treat HIV infection), irinotecan (anticancer medicine), and warfarin (anticoagulant medicine) is contraindicated.
Special caution is advised when using medicines that are metabolized by CYP3A4, CYP2C9, CYP2C19, or P-glycoprotein enzymes, such as amitriptyline (antidepressant), fexofenadine (antihistamine), benzodiazepines (anxiolytic medicines), methadone (pain reliever), simvastatin (lipid-lowering medicine), digoxin (medicine used to treat heart failure), finasteride (medicine used to treat benign prostatic hyperplasia), as their plasma concentrations may be reduced.
A decrease in the plasma concentration of oral contraceptives may lead to intermenstrual bleeding and reduced efficacy of hormonal contraception.
Women taking oral hormonal contraceptives should use additional non-hormonal contraceptive methods.
Before planned surgery, the possibility of interactions with medicines used for general and local anesthesia should be considered. If necessary, the medicine containing St. John's Wort extract should be discontinued.
Increased enzyme activity returns to normal within 1 week after stopping the medicine containing St. John's Wort extract.
St. John's Wort extract may contribute to the intensification of serotonergic effects, such as nausea, vomiting, anxiety, agitation, and confusion, if used in combination with antidepressant medicines, such as selective serotonin reuptake inhibitors (e.g., sertraline, paroxetine, nefazodone) or triptans and buspirone.
In patients taking other prescription medicines before starting treatment with St. John's Wort extract, consultation with a doctor or pharmacist is recommended.

Using Depremin 612mg with food and drink

The medicine should be taken with a sufficient amount of liquid, preferably water.

Pregnancy, breastfeeding, and fertility

Use during pregnancy and breastfeeding is not recommended.

Driving and using machines

There are no adequate studies on the effect on the ability to drive and use machines.

3. How to take Depremin 612mg

This medicine should always be taken exactly as described in the package leaflet or as directed by your doctor or pharmacist.
In case of doubt, the patient should consult their doctor or pharmacist.
Recommended dose:
Adults: one tablet (612 mg), once a day.
Method of administration:
Oral use.
Duration of treatment:
6 weeks.
Therapeutic effect can be expected within 4 weeks of treatment. If symptoms persist during treatment, the patient should consult their doctor.

Use in children and adolescents

Due to the lack of sufficient data, the use of Depremin 612mg in children and adolescents under 18 years of age is not recommended.

Taking a higher dose of Depremin 612mg than recommended

After ingestion of up to 4.5 g of dry extract per day for 2 weeks and an additional 15 g of dry extract before hospitalization, seizures and confusion occurred.
After overdose, the patient should be protected from sunlight and other sources of UV radiation for 1-2 weeks.

Missing a dose of Depremin 612mg

A double dose should not be taken to make up for a missed dose (1 tablet).

Stopping treatment with Depremin 612mg

In case of any further doubts about the use of this medicine, the patient should consult their doctor or pharmacist.

4. Possible side effects

Like all medicines, Depremin 612mg can cause side effects, although not everybody gets them.
Gastrointestinal disorders, allergic skin reactions, fatigue, and anxiety may occur.
The frequency of these side effects is not known.
During intense sun exposure, people with fair skin may experience intensified symptoms, such as sunburn.
If other side effects occur, not listed above, the patient should consult their doctor or pharmacist.

Reporting side effects

If any side effects occur, including any possible side effects not listed in the package leaflet, the patient should inform their doctor or pharmacist, or nurse.
Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products:
Al. Jerozolimskie 181C, 02-222 Warsaw, tel.: +48 22 49-21-301, fax: +48 22 49-21-309, website: https://smz.ezdrowie.gov.pl
Side effects can also be reported to the marketing authorization holder.
Reporting side effects will help to gather more information on the safety of the medicine.

5. How to store Depremin 612mg

Store in a temperature below 25°C.
The medicine should be stored out of sight and reach of children.
Do not use this medicine after the expiry date stated on the carton after EXP (abbreviation used to describe the expiry date). The expiry date refers to the last day of the month.
Medicines should not be disposed of via wastewater or household waste. The patient should ask their pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. Contents of the pack and other information

What Depremin 612mg contains

The active substance is dry extract of St. John's Wort ( Hyperici herbae extractum siccum quantificatum)
One coated tablet contains 612 mg of extract (in the form of dry extract, quantified) from Hypericum perforatumL., herba (St. John's Wort) (DER 3-6:1), which corresponds to: 0.6 mg - 1.8 mg of hypericin, 36.72 mg - 91.80 mg of flavonoids in terms of rutin, not more than 36.72 mg of hyperforin.
Extraction solvent: ethanol 60% (V/V)
Other excipients are: colloidal anhydrous silica, microcrystalline cellulose, sodium croscarmellose, colloidal anhydrous silica, magnesium stearate, coating mixture Opadry II 85F32410 yellow (polyvinyl alcohol, titanium dioxide, macrogol 3350, talc, yellow iron oxide (E 172)).

What Depremin 612mg looks like and contents of the pack

Oblong, biconvex, coated tablet, yellow in color.
Depremin 612mg is available in packs containing: 20, 30, or 60 tablets in PVC/PVDC/Aluminum blisters in a cardboard box.

Marketing authorization holder and manufacturer

Zakłady Farmaceutyczne „COLFARM” S.A.
ul. Wojska Polskiego 3

Date of last revision of the package leaflet: July 2024

  • Country of registration
  • Prescription required
    No
  • Manufacturer
  • Importer
    Zakłady Farmaceutyczne COLFARM S.A.
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Online doctors for Depremin 612 mg

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Depremin 612 mg – subject to medical assessment and local rules.

5.0(25)
Doctor

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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She treats adults with respiratory illnesses such as pneumonia, COPD and bronchial asthma, as well as cardiovascular conditions including hypertension and ischaemic heart disease. Her practice also covers gastrointestinal complaints and chronic comorbidities that require careful, structured medical supervision.

Dr Boichuk provides care for children from birth, including acute respiratory viral infections, infectious diseases, pneumonia, bronchitis, bronchial obstruction syndromes and allergic reactions. She offers clear, evidence-based guidance to parents and ensures safe follow-up throughout the child’s recovery.

Her work also includes developing personalised immunisation plans and supporting families with long-term preventive care.

Known for her structured clinical approach and clear communication, Dr Liudmyla Boichuk offers patients of all ages comprehensive, reliable and evidence-based medical care.

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Dr Oleksandr Babushkin is an orthopaedic and trauma specialist providing online consultations for adults with joint, muscle, and spine-related concerns. He helps patients accurately assess symptoms, manage chronic and acute musculoskeletal conditions, and build effective recovery strategies through evidence-based care.

Online consultations include:

  • Evaluation of musculoskeletal symptoms: acute or chronic pain, stiffness, and reduced mobility.
  • Diagnosis and treatment advice for joint pain (knees, hips, shoulders, elbows), back and neck pain.
  • Support for conditions such as osteoarthritis, bursitis, tendinitis, and nerve compression syndromes.
  • Guidance after injuries: strains, sprains, bruises, suspected fractures, and overuse injuries.
  • Recovery support following orthopaedic surgery or trauma.
  • Monitoring treatment progress and adjusting therapy based on your symptoms and test results.

You can book a consultation if you experience:

  • Joint pain, limited mobility, or cracking sounds during movement.
  • Back or neck pain, especially with prolonged sitting or physical activity.
  • Chronic discomfort that affects your daily life or sleep.
  • Need for post-surgical follow-up or rehabilitation planning.

Dr Babushkin combines his expertise in orthopaedics and trauma care with a personalised, structured approach — helping patients regain mobility, reduce pain, and improve quality of life.

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She offers expert care for:

  • Headaches and migraines, including tension-type and cluster headaches.
  • Neck and back pain, both acute and chronic.
  • Chronic pain syndromes – fibromyalgia, neuropathic pain, post-traumatic pain.
  • Mononeuropathies – carpal tunnel syndrome, trigeminal neuralgia, facial nerve palsy.
  • Polyneuropathies – diabetic, toxic, and other types.
  • Multiple sclerosis – diagnosis, monitoring, long-term support.
  • Dizziness and coordination disorders.
  • Sleep disturbances – insomnia, daytime sleepiness, fragmented sleep.
  • Anxiety, depression, and stress-related conditions.

Dr. Agapova helps patients manage complex neurological symptoms like pain, numbness, weakness, poor sleep, and emotional distress. Her consultations focus on accurate diagnosis, clear explanation of findings, and tailored treatment plans.

If you’re struggling with chronic pain, migraines, nerve disorders, or sleep problems, Dr. Agapova offers professional guidance to restore your well-being.

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Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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His areas of expertise include:

  • Preventive care and vaccination planning, including catch-up schedules for children.
  • Assessment of psychomotor, emotional, and physical development.
  • Diagnosis, treatment planning, and clinical monitoring for paediatric conditions.
  • Nutritional guidance for infants, including the choice of adapted milk formulas tailored to medical needs.
  • Early identification of rare and orphan diseases.
  • Ongoing care for children with chronic or complex health conditions.
By combining paediatrics with a personalised approach, Dr. Savin ensures professional support that addresses both the physical health and overall well-being of children, while guiding parents at every stage of their child’s growth.
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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Mar Tabeshadze

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  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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Areas of expertise:

  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
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