Cinnarizinum Hasco

Package Leaflet: Information for the Patient

CINNARIZINUM HASCO

25 mg, tablets
Cinnarizinum

Read the leaflet carefully before taking the medicine, as it contains important information for the patient.

• Keep this leaflet, you may need to read it again.
• If you have any further questions, ask your doctor, pharmacist, or nurse.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
• If you experience any side effects, including those not listed in this leaflet, please inform your doctor, pharmacist, or nurse. See section 4.

Table of Contents of the Leaflet

• 1. What is Cinnarizinum Hasco and what is it used for
• 2. Important information before taking Cinnarizinum Hasco
• 3. How to take Cinnarizinum Hasco
• 4. Possible side effects
• 5. How to store Cinnarizinum Hasco
• 6. Contents of the pack and other information

1. What is Cinnarizinum Hasco and what is it used for

Cinnarizine counteracts the contraction of vascular smooth muscle caused by the action of many substances (including adrenaline, noradrenaline, serotonin, dopamine) through a common mechanism involving a decrease in the permeability of the smooth muscle cell membrane to calcium and thereby inhibiting its entry into the cells. This results in the dilation of cerebral and peripheral blood vessels, improving circulation and tissue oxygenation.
Cinnarizine reduces the stimulation of the vestibular system. It has antiemetic and slightly sedative effects.
Cinnarizine is a histamine H1 receptor antagonist and has antiallergic properties.
Indications for use:

• treatment of symptoms of vestibular disorders and Meniere's disease, such as dizziness, nausea, vomiting;
• prevention of motion sickness;
• treatment of symptoms of cerebral and peripheral circulatory disorders (e.g., dizziness, tinnitus, headaches) and peripheral (e.g., intermittent claudication, Raynaud's disease).

2. Important information before taking Cinnarizinum Hasco

When not to take Cinnarizinum Hasco:

• if you are allergic to cinnarizine or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Before taking Cinnarizinum Hasco, you should discuss it with your doctor, pharmacist, or nurse.
Cinnarizine does not cause significant lowering of blood pressure. However, when taking cinnarizine in high doses (150 mg/day) or in patients with hypotension, caution should be exercised.
Patients with porphyria should not take cinnarizine.
In patients with Parkinson's disease, cinnarizine may only be administered if the expected benefits outweigh the potential risk of exacerbating the disease.

Cinnarizinum Hasco and other medicines

Inform your doctor or pharmacist about all the medicines you are taking or have recently taken, as well as any medicines you plan to take.
Cinnarizine enhances the sedative effect of medicines that depress the central nervous system, such as tricyclic antidepressants, anxiolytics, hypnotics, and opioid analgesics.
Antihistamines may inhibit the skin reaction to allergens caused by histamine, so cinnarizine should be discontinued a few days before skin tests are performed.

Cinnarizinum Hasco with food, drink, and alcohol

Like other antihistamines, cinnarizine may cause stomach upset. Therefore, it is recommended to take the medicine after a meal.
Alcohol enhances the sedative and hypnotic effects of cinnarizine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

Cinnarizinum Hasco may cause drowsiness and impaired physical and mental performance, and ability to drive and operate machinery.

Cinnarizinum Hasco contains lactose

If you have been diagnosed with an intolerance to some sugars, consult your doctor before taking the medicine.

3. How to take Cinnarizinum Hasco

Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, ask your doctor or pharmacist.
The medicine should be taken orally.
The medicine is for use in adults.
Vestibular disorders: 1 tablet 3 times a day.
Motion sickness: 1 tablet 2 hours before travel. Then, if necessary, 1 tablet every 8 hours during travel.
Do not exceed the dose of 150 mg (6 tablets) per day.

Overdose of Cinnarizinum Hasco

Symptoms of overdose are: vomiting, drowsiness, hypotension, gait disturbances, hallucinations, stupor, and even coma, which may be preceded by increased stimulation, including motor, oculogyric crisis, significant increase in body temperature (hyperthermia), and convulsions. Severe overdose symptoms include: acute respiratory failure, metabolic acidosis, convulsions, acute renal failure, muscle tissue damage (rhabdomyolysis), and hypothermia.
There is no specific antidote for cinnarizine, but in case of overdose, gastric lavage and activated charcoal may be administered.
If you have taken more than the recommended dose of the medicine, seek medical attention immediately.

Missed dose of Cinnarizinum Hasco

Do not take a double dose to make up for a forgotten dose.

4. Possible side effects

Like all medicines, Cinnarizinum Hasco can cause side effects, although not everybody gets them.
The medicine may cause drowsiness, fatigue, dizziness, gastrointestinal disturbances, which are usually transient.
Dryness of the mucous membranes of the mouth and increased thirst may occur.
Rarely, the following may occur: weight gain, headache, excessive sweating, and allergic reactions.
In rare cases, extrapyramidal disorders (e.g., tremor, muscle stiffness, hypokinesia - decreased mobility) and depression - mainly in elderly patients during long-term use - may be exacerbated or occur. In such cases, the use of the medicine should be discontinued.
Very rarely, the following may occur: lichen planus, skin changes similar to those in lupus, jaundice.

Reporting side effects

If you experience any side effects, including those not listed in this leaflet, please inform your doctor or pharmacist. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products:
Aleje Jerozolimskie 181C, 02-222 Warsaw
tel.: +48 22 49 21 301, fax: +48 22 49 21 309
e-mail: ndl@urpl.gov.pl
Side effects can also be reported to the marketing authorization holder.
Reporting side effects will help to gather more information on the safety of the medicine.

5. How to store Cinnarizinum Hasco

Store in a temperature below 25°C. Store in the original package to protect from light and moisture.
Keep the medicine out of the sight and reach of children.
Do not use the medicine after the expiry date stated on the package. The expiry date refers to the last day of the month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

What Cinnarizinum Hasco contains

• The active substance is cinnarizine. One tablet contains 25 mg of cinnarizine.
• The other ingredients (excipients) are: lactose monohydrate, sodium carboxymethylcellulose (type A), microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate.

What Cinnarizinum Hasco looks like and contents of the pack

Cinnarizinum Hasco is a white, biconvex, smooth tablet.
One pack of the medicine contains 50 tablets.

Marketing authorization holder and manufacturer

“PRZEDSIĘBIORSTWO PRODUKCJI FARMACEUTYCZNEJ HASCO-LEK” S.A.
51-131 Wrocław, ul. Żmigrodzka 242 E

Medicine information

tel. +48 22 742 00 22
e-mail: informacjaoleku@hasco-lek.pl

Date of last revision of the leaflet: