Hronada

PATIENT INFORMATION LEAFLET

Leaflet attached to the packaging: patient information

Chronada, 200 mg + 250 mg, hard capsules

Sodium chondroitin sulfate + Glucosamine hydrochloride

Read the leaflet carefully before taking the medicine, as it contains important information for the patient.

• Keep this leaflet, so you can read it again if you need to.
• If you have any doubts, consult your doctor or pharmacist.
• This medicine has been prescribed specifically for you. Do not pass it on to others. The medicine may harm another person, even if their symptoms are the same. If you experience any side effects, inform your doctor or pharmacist. Inform your doctor or pharmacist about any side effects not listed in this leaflet. See section 4.

Table of contents of the leaflet:

• 1. What is Chronada and what is it used for
• 2. Important information before taking Chronada
• 3. How to take Chronada
• 4. Possible side effects
• 5. How to store Chronada
• 6. Package contents and other information

1. What is Chronada and what is it used for

Chronada is a hard capsule medicine that contains two active ingredients. The first active ingredient is sodium chondroitin sulfate, and the second is glucosamine hydrochloride. Both active ingredients belong to the group of non-steroidal anti-inflammatory and anti-rheumatic medicines. Chronada is used to treat the symptoms of knee osteoarthritis in adults with moderate to severe pain, for whom combined treatment with chondroitin sulfate and glucosamine hydrochloride is appropriate.

2. Important information before taking Chronada

When not to take Chronada:

• If you are allergic to sodium chondroitin sulfate, glucosamine hydrochloride, or any of the other ingredients of this medicine (listed in section 6).
• If you are allergic to shellfish, as glucosamine is derived from shellfish.

Warnings and precautions

Before starting treatment with Chronada, discuss it with your doctor or pharmacist:

• If you have impaired glucose tolerance, it may be necessary to check your blood sugar levels more frequently before starting treatment with glucosamine.
• If you have or have had kidney or liver dysfunction, as no studies have been conducted in such patients, and therefore, no specific dosage recommendations can be provided.
• If you have any serious heart conditions, consult your doctor.

Children and adolescents

This medicine is not recommended for children and adolescents under 18 years of age.

Chronada and other medicines

Tell your doctor or pharmacist about all the medicines you are taking, or have recently taken, and about any medicines you plan to take. Be cautious when taking Chronada in combination with other medicines, especially:

• certain types of medicines used to prevent blood clotting (e.g., warfarin, dicumarol, phenprocoumon, acenocoumarol, and fluindione). The effect of these medicines may be stronger when taken with glucosamine. Patients treated with such combinations of medicines should be closely monitored when starting or stopping glucosamine treatment.
• or medicines used to treat infections (antibiotics such as tetracycline, chloramphenicol, or penicillin).

For additional information, consult your doctor or pharmacist.

Chronada with food and drink

The capsules can be taken before meals, during meals, or after meals. If you are prone to stomach problems, it is recommended to take the medicine after a meal.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, consult your doctor or pharmacist before taking this medicine. It is not known whether the active substances of Chronada pass into breast milk. Do not take this medicine if you are breastfeeding, as there is not enough data on the effect on the child's health. Before taking any medicine, consult your doctor or pharmacist.

Driving and using machines

If you experience dizziness or drowsiness, do not drive or operate machinery.

3. How to take Chronada

Always take this medicine exactly as your doctor has told you. If you are unsure, consult your doctor or pharmacist. The recommended dose is 2 capsules taken 3 times a day. Swallow the capsules whole with a sufficient amount of liquid.

Taking a higher dose of Chronada than recommended

If you take more capsules than recommended, you may experience headaches, dizziness, disorientation, joint pain, nausea, vomiting, or diarrhea, but it is likely that none of these symptoms will occur. If you experience any of these symptoms, consult your doctor.

Missing a dose of Chronada

You can take a missed dose at any time, but do not take more than 6 capsules per day.

Stopping treatment with Chronada

There may be a recurrence of symptoms. If you have any doubts about taking this medicine, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Immediately inform your doctor if you experience any of the following side effects: Upper respiratory tract infection, urinary tract infection, or chest pain.

The most common side effects of Chronada are:

• headache
• diarrhea, nausea, indigestion, bloating (gas)

Rare (may affect up to 1 in 1000 people):

• taste disorders
• abdominal pain
• gastroesophageal reflux disease (a condition in which food or liquid returns from the stomach to the esophagus)
• constipation, heartburn, abdominal bloating
• muscle cramps, limb pain
• fatigue
• upper respiratory tract infection, urinary tract infection
• increased liver enzyme activity
• abnormal urine test results

Side effects observed in patients treated with chondroitin sulfate alone (other than those listed above) are listed below:

• edema, fluid retention
• allergic reaction

Side effects observed in patients treated with glucosamine hydrochloride alone (other than those listed above) are listed below:

• redness or rash on the skin and itching

Frequency not known (cannot be estimated from the available data):

• facial edema, tongue or throat edema
• hives, edema in the ankles, feet, and legs
• dizziness, vomiting
• worsening of blood test results in diabetic patients

In general, the side effects that may occur during treatment with this medicine are mild and temporary, and they disappear after stopping the treatment. If you experience any side effects that are serious or if you notice any side effects not listed in this leaflet, inform your doctor or pharmacist.

Reporting side effects

If you experience any side effects, including those not listed in this leaflet, inform your doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Adverse Reaction Monitoring of Medicinal Products, Medical Devices, and Biocidal Products, Al. Jerozolimskie 181C, 02-222 Warsaw, Tel.: +48 22 49 21 301, Fax: +48 22 49 21 309, website: https://smz.ezdrowie.gov.pl. Side effects can also be reported to the marketing authorization holder. By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Chronada

Do not store the medicine above 30°C. Store the medicine in its original packaging to protect it from moisture. Keep the medicine out of sight and reach of children. Do not use this medicine after the expiry date stated on the carton. The expiry date refers to the last day of the month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package contents and other information

What Chronada contains

• The active substances are sodium chondroitin sulfate, produced from bovine cartilage, and glucosamine hydrochloride. Each capsule contains 200 mg of sodium chondroitin sulfate and 250 mg of glucosamine hydrochloride.
• The other ingredient is magnesium stearate.

What Chronada looks like and contents of the pack

Chronada is a turquoise-colored hard gelatin capsule. Chronada is available in a cardboard box containing 90 capsules in blisters. Each package contains 6 blisters of 15 capsules. The blister is made of PVC/PVDC-Aluminum.

Marketing authorization holder and manufacturer

LABORATORIO REIG JOFRE, S.A., Gran Capitán 10, 08970 Sant Joan Despí (Barcelona), Spain

Manufacturer

NOUCOR HEALTH, S.A., Avda. Camí Reial 51-57, Palau-Solità i Plegamans, 08184 Barcelona, Spain, or SINCROFARM, S.L., c/ Mercuri, 10. Pol. Ind. Almeda, 08940 Cornellà de Llobregat (Barcelona), Spain, or Adamed Pharma S.A., ul. Marszałka Józefa Piłsudskiego 5, 95-200 Pabianice, Poland

Representative of the marketing authorization holder

Adamed Pharma S.A., Pieńków, ul. M. Adamkiewicza 6A, 05-152 Czosnów, Poland

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

Finland: Droglican, Austria, France: Cartifit, Hungary: Droglycan, Poland: Chronada

Date of last revision of the leaflet: January 2025