16 mg, tablets
Candesartan cilexetil
The name of the medicine is Carzap. The active substance of the medicine is candesartan cilexetil. It belongs to a group of medicines called angiotensin II receptor antagonists. It causes relaxation and dilation of blood vessels. This helps to lower blood pressure. The medicine also makes it easier for the heart to pump blood to all parts of the body.
Carzap is used:
In case of doubts about whether any of the above situations apply to the patient, the doctor or pharmacist should be consulted before taking Carzap.
Before starting to take Carzap, the doctor or pharmacist should be consulted:
The doctor may monitor kidney function, blood pressure, and electrolyte levels (e.g., potassium) in the blood at regular intervals.
See also the information under the heading "When not to take Carzap".
If any of the above conditions apply to the patient, the doctor may recommend more frequent checks and tests.
If the patient is going to undergo surgery, they should inform the doctor or dentist about taking Carzap. This is because Carzap, in combination with some anesthetics, may cause excessive lowering of blood pressure.
Studies have been conducted on the use of candesartan cilexetil in children. For further information, the doctor should be consulted. Carzap should not be given to children under 1 year of age due to the potential risk to kidney development.
The doctor or pharmacist should be told about all medicines the patient is taking or has recently taken, as well as any medicines the patient plans to take.
Carzap may affect the action of other medicines, and other medicines may affect Carzap. If the patient is taking certain medicines, the doctor may periodically recommend blood tests.
Particularly, the doctor should be informed if the patient is taking any of the following medicines:
aspirin (in a dose greater than 3 g per day), (a medicine that relieves pain and inflammation);
The doctor may need to change the dose and/or take other precautions:
While taking Carzap, the doctor should be consulted if alcohol consumption is planned. Alcohol may cause dizziness or fainting.
Pregnancy
If the patient suspects she may be pregnant (or plans to have a child), she should consult her doctor. The doctor will usually recommend stopping Carzap before planned pregnancy or as soon as pregnancy is confirmed, and recommend taking another medicine instead of Carzap. It is not recommended to take Carzap in early pregnancy and it should not be taken after 3 months of pregnancy, as it may seriously harm the fetus.
Breastfeeding
The doctor should be informed about breastfeeding or intention to breastfeed. It is not recommended to take Carzap during breastfeeding, especially in the case of breastfeeding a newborn or premature baby. The doctor may recommend taking another medicine.
While taking Carzap, some patients may feel tired and dizzy. If such symptoms occur, the patient should not drive, use tools, or operate machines.
Carzap contains lactose monohydrate, which is a type of sugar. If the patient has previously been diagnosed with intolerance to some sugars, they should contact their doctor before taking Carzap.
The medicine contains less than 1 mmol (23 mg) of sodium per tablet, which means it is considered "sodium-free".
This medicine should always be taken as directed by the doctor or pharmacist. In case of doubts, the doctor or pharmacist should be consulted.
Carzap is available in the following strengths: 8 mg, 16 mg, 32 mg.
It is important to take Carzap every day. Carzap can be taken with or without food. The tablet should be swallowed with water. The tablets should be taken every day at about the same time. This will help the patient remember to take the dose.
The doctor may recommend a lower initial dose in certain patients, e.g., patients with liver or kidney problems, patients who have lost a lot of fluid, e.g., due to vomiting, diarrhea, or diuretic use.
The recommended initial dose is 4 mg once a day.
Patients with a body weight <50 kg: in patients whose blood pressure is not adequately controlled, the doctor may decide to increase dose a maximum of 8 mg once day.
Patients with a body weight ≥50 kg: in patients whose blood pressure is not adequately controlled, the doctor may decide to increase the dose to 8 mg once a day, and then to 16 mg once a day.
The recommended initial dose of Carzap is 4 mg once a day. The doctor may increase the dose by doubling it, at intervals of at least 2 weeks, to 32 mg once a day. Carzap can be taken with other medicines used to treat heart failure, and the doctor will decide which treatment is most suitable for the patient.
In case of taking a higher dose of Carzap than recommended by the doctor, the doctor or pharmacist should be contacted immediately.
A double dose should not be taken to make up for a missed dose. The next dose should be taken at the usual time.
If treatment with Carzap is stopped, blood pressure may rise again.
Therefore, treatment with Carzap should not be stopped without prior consultation with the doctor.
In case of any further doubts about taking this medicine, the doctor or pharmacist should be consulted.
Like all medicines, Carzap can cause side effects, although not everybody gets them.
It is important for the patient to know that they can occur.
Carzap may cause a decrease in the number of white blood cells. The patient's resistance to infection may be decreased, and they may experience fatigue, infection, or fever. If such symptoms occur, the doctor should be contacted. The doctor may recommend periodic blood tests to check if Carzap is affecting the blood (agranulocytosis).
Other possible side effects include:
In children treated for high blood pressure, side effects seem to be similar to those in adults, but they occur more frequently. A very common side effect in children, not reported in adults, is a sore throat. Additionally, side effects such as a runny nose, fever, and rapid heartbeat in children occur frequently, while in adults, they were not reported.
If the patient experiences any side effects, including any side effects not listed in the leaflet, they should inform their doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Adverse Reaction Monitoring of Medicinal Products, Medical Devices, and Biocidal Products,
Jerozolimskie Avenue 181C, 02-222 Warsaw, tel.: 22 49-21-301, fax: 22 49-21-309, website:
https://smz.ezdrowie.gov.pl
By reporting side effects, more information can be collected on the safety of the medicine.
The medicine should be stored out of sight and reach of children.
The medicine should not be used after the expiry date stated on the packaging. The expiry date refers to the last day of the month.
There are no special storage precautions.
Medicines should not be disposed of via wastewater or household waste. The pharmacist should be asked how to dispose of medicines that are no longer needed. This will help protect the environment.
The active substance of the medicine is candesartan cilexetil.
Each tablet contains 16 mg of candesartan cilexetil.
The other ingredients are: lactose monohydrate, cornstarch, hydroxypropylcellulose (E 463),
crosxcarmellose sodium (E 468), magnesium stearate (E 572), triethyl citrate (E 1505).
Carzap, 16 mg, is a round, biconvex, white or almost white tablet with a score line on one side and the imprint C/16 on the same side. The diameter of the tablet is approximately 8 mm.
The tablet can be divided into equal doses.
Pack sizes: 14, 28, 56, or 98 tablets.
For more detailed information, the marketing authorization holder or parallel importer should be contacted.
Zentiva, k. s., U Kabelovny 130, 102 37 Prague 10, Czech Republic
Zentiva, k. s., U Kabelovny 130, 102 37 Prague 10, Czech Republic
Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź
Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź
Marketing authorization number in the Czech Republic, the country of export: 58/746/11-C
[Information about the trademark]
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